Canine pituitary macrotumors.

Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas

PURPOSE Cushing's disease (CD), also known as pituitary-dependent hyperadrenocorticism, is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary tumours. Affected humans and dogs have similar clinical manifestations, however, the incidence of the canine disease is thousand-fold higher. This makes the dog an obvious model for studying the pathogenesis of pituitary-dependent hyperadren...

Granulocyte Function Canine Polymorphonuclear Neutrophil Pituitary Canine Growth Hormone on Characterization of the Priming

Early stages of development of rat brain tumors induced by JC virus: a sequential histological and immunohistochemical study.

In order to clarify the origin of JC virus-induced brain tumors in rats, the development of tumors was sequentially analyzed histologically and immunohistochemically. Twenty-two of 30 rats (73%), which were intracerebrally inoculated with JC virus within 24 h of birth (group 1), developed, as a group, 45 brain tumors after 12 to 26 weeks. Seventeen of 27 rats (63%), which were inoculated on the...

Selegiline Treatment of Canine Pituitary- Dependent Hyperadrenocorticism

Hypothalamic-Adenohypophyseal Disorders • Selegiline Treatment of Canine Pituitary‐Dependent Hyperadrenocorticism • Selegiline Effects on Responses to Medetomidine, Oxymorphone, or Butorphanol in Dogs • Double Pituitary Adenoma Associated With Diabetes Mellitus and Hyperadrenocorticism • Effects of Budesonide on Hypothalamic‐ Pituitary‐Adrenal Axis in Dogs Tests of Thyroid Function • Thyroid Ho...

Effects of Carbenoxolone on the Canine Pituitary-Adrenal Axis

Cushing's disease caused by pituitary corticotroph adenoma is a common endocrine disease in dogs. A characteristic biochemical feature of corticotroph adenomas is their relative resistance to suppressive negative feedback by glucocorticoids. The abnormal expression of 11beta-hydroxysteroid dehydrogenase (11HSD), which is a cortisol metabolic enzyme, is found in human and murine corticotroph ade...